Psychotropic Medications and the Risk of Sudden Cardiac Death

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Psychotropic Medications and the Risk of Sudden Cardiac Death

S udden cardiac death (SCD) accounts 1 out of 2 deaths from cardiovascular diseases. Identification of factors increasing the risk of SCD has been a challenge for both scientists and clinicians for decades, and the risk factors of SCD have been intensively studied. Some factors have already been identified that increase the risk of SCD. Currently recognized risk factors mainly reflect the demog...

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Psychotropic medications and the risk of sudden cardiac death during an acute coronary event.

AIMS Psychotropic medication increases cardiac mortality, but the reasons for this association are not clear. We studied the role of psychotropic drugs as a triggering factor of sudden cardiac death (SCD) during an acute coronary event. METHODS AND RESULTS The use of medication was compared between victims of SCD and survivors of an acute coronary event in a case-control study including a con...

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Psychotropic drugs, cardiac arrhythmia, and sudden death.

A variety of drugs targeted towards the central nervous system are associated with cardiac side effects, some of which are linked with reports of arrhythmia and sudden death. Some psychotropic drugs, particularly tricyclic antidepressants (TCAs) and antipsychotic agents, are correlated with iatrogenic prolongation of the QT interval of the electrocardiogram (ECG). In turn, this is associated wi...

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Psychotropic Medications, Associated QTc Prolongation, and Sudden Cardiac Death: A Review for Clinicians

Prolongation of QTC is an electrocardiographic finding indicating prolongation of cardiac repolarization, which increases the risk for torsades de pointes, a form of ventricular tachycardia that can lead to sudden cardiac death. Sudden cardiac death in the setting of antipsychotic treatment was first described in the 1960s with thioridazine; since that time, many other psychotropic medications ...

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Sudden Death of Cardiac Origin and Psychotropic Drugs

Mortality rate is high in psychiatric patients versus general population. An important cause of this increased mortality is sudden cardiac death (SCD) as a major side-effect of psychotropic drugs. These SCDs generally result from arrhythmias occurring when the posology is high and may attain a toxic threshold but also at dosages within therapeutic range, in the presence of risk factors. There a...

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ژورنال

عنوان ژورنال: Journal of the American Heart Association

سال: 2015

ISSN: 2047-9980,2047-9980

DOI: 10.1161/jaha.115.001894